Enantiomer separation of acidic compounds
نویسندگان
چکیده
CHIRALPAK QN-AX and QD-AX are anion exchanger chiral stationary phases providing specifi c enantioselectivity for acidic compounds. In this Application Note, we demonstrate that the application of these columns can be extended to supercritical fl uid chromatography (SFC) for enantiomer separation of acidic compounds. Using the advantages of the advanced technology of the Agilent 1260 Infi nity Analytical SFC system, we were able to assess the infl uence of a series of parameters such as the mobile phase additives and the fl ow rate to gain insight into the general approaches for method development and optimization. Authors Tong Zhang, Dung Nguyen, Pilar Franco Chiral Technologies, Europe Illkirch, France Martin Vollmer Agilent Technologies, Inc. Waldbronn, Germany min 0 2 4 6 8 10 OH O
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